原著論文Original Article

  • 2004)
    • Takematsu H, Yamamoto H, Okuno Y, Kannagi R, Suzuki A, Kozutsumi Y. “DNA microarray analysis of genes responsible for the expression of carbohydrate epitopes” Glycobiology. 2004;14:1201-1201 525.
    • Kotera M, Okuno Y, Hattori M, Goto S, Kanehisa M. “Computational assignment of the EC numbers for genomic-scale analysis of enzymatic reactions” J. Am. Chem. Soc.　2004;126:16487-98. Available from: https://doi.org/10.1021/ja0466457
    • Sugimoto Y, Tsuboi H, Okuno Y, Tamba S, Tsuchiya S, Tsujimoto G, Ichikawa A. “Microarray evaluation of EP4 receptor mediated prostaglandin E2 suppression of 3T3-L1 adipocyte differentiation” Biochem. Biophys. Res. Commun. 2004;322:911-7. Available from: https://doi.org/10.1016/j.bbrc.2004.07.194
    • Mamitsuka H, Okuno Y. “A hierarchical mixture of Markov models for finding biologically active metabolic paths using gene expression and protein classes” Proceedings of the IEEE Computational Systems Bioinformatics Conference (CSB 2004). 2004:341-52. Available from: https://doi.org/10.1109/csb.2004.1332447
    • Kanehisa M, Goto S, Kawashima S, Okuno Y, Hattori M. “The KEGG resource for deciphering the genome” Nucleic Acids Res. 2004;32:D277-80. Available from: https://doi.org/10.1093/nar/gkh063
  • 2003)
    • Mamitsuka H, Okuno Y, Yamaguchi A. “Mining biologically active patterns in metabolic pathways using microarray expression profiles” ACM SIGKDD Explor. 2003;5:113-21. Available from: https://doi.org/10.1145/980972.980986
    • Hattori M, Okuno Y, Goto S, Kanehisa M. “Heuristics for chemical compound matching”Genome Inform. 2003;14:144-53. Available from: https://www.jstage.jst.go.jp/article/gi1990/14/0/14_0_144/_pdf
    • Aoki K.F, Yamaguchi A, Okuno Y, Akutsu T, Ueda N, Kanehisa M, Mamitsuka H. “Efficient tree-matching methods for accurate carbohydrate database queries” Genome Inform. 2003;14:134-43. Available from: https://doi.org/10.11234/gi1990.14.134
    • Hattori M, Okuno Y, Goto S, Kanehisa M. “Development of a chemical structure comparison method for integrated analysis of chemical and genomic information in the metabolic pathways” J. Am. Chem. Soc. 2003;125:11853-65. Available from: https://doi.org/10.1021/ja036030u
    • Limviphuvadh V, Okuno Y, Katayama T, Goto S, Yoshizawa A, Kanehisa M. “Metabbolic pathway reconstruction for malaria parasite Plasmodium falciparum” Genome Informatics. 2003;14:38-39. Available from: https://doi.org/10.11234/gi1990.14.368
    • Kawano S, Okuno Y, Hashimoto K, Yamamoto H, Takematsu H, Kozutsumi Y, Goto S, Kanehisa M. “Prediction of glycan structures from glycosyltransferase ecxpression profile” Genome Informatics. 2003;14:304-5. Available from: https://doi.org/10.11234/gi1990.14.304
    • Aoki K, Yamaguchi A, Okuno Y, Akutsu T, Ueda N, Kanehisa M, Mamitsuka H , Statistical Significance of Tree Similarity Scores , Genome Informatics , 14 , 579-580 , 2003 https://doi.org/10.11234/gi1990.14.579
  • 2002)
  • 2001)
  • 2000)
    • Hori Y, Suzuki K, Okuno Y, Nagaoka M, Futaki S, Sugiura Y. “Artificial zinc finger peptide containing a novel His4 domain” J. Am. Chem. Soc. 2000;122:7648-53. Available from: https://doi.org/10.1021/ja994009g
    • Okuno Y, Iwashita T, Sugiura Y. “Structural basis for reaction mechanism and drug delivery system of chromoprotein antitumor antibiotics C-1027” J. Am. Chem. Soc. 2000;122:6848-54. Available from: https://doi.org/10.1021/ja994323a
    • Hori Y, Suzuki K, Okuno Y, Nagaoka M, Futaki S, Sugiura Y. “The engineering, structure, and DNA binding properties of a novel His4-type zinc finger peptide” Nucleic Acids Symp. Ser. 2000;44:295-96. Available from: https://doi.org/10.1093/nass/44.1.295
    • Araki M, Okuno Y, Sugiura Y. “Expression mechanism of the allosteric interactions in a ribozyme catalysis” Nucleic Acids Symp. Ser. 2000;44:205-06. Available from: https://doi.org/10.1093/nass/44.1.205
  • 1998)
    • Araki M, Okuno Y, Hara Y, Sugiura Y. “Allosteric regulation of a ribozyme activity through ligand-induced conformational change” Nucleic Acids Res. 1998;26:3379-84. Available from: https://doi.org/10.1093/nar/26.14.3379
  • 1997)
    • Sugiura Y, Totsuka R, Araki M, Okuno Y. “Selective cleavages of tRNAphe with secondary and tertiary structures by enediyne antitumor antibiotics” Bioorg. Med. Chem. 1997;5:1229-34. Available from: https://doi.org/10.1016/s0968-0896(97)00052-7
  • 1996)
    • Okuno Y, Iwashita T, Otani T, Sugiura Y. “Interaction of C-1027 chromophore with d(GTATAC)2: A binding model based on NMR experiments” J. Am. Chem. Soc. 1996;118:4729-30. Available from: https://doi.org/10.1021/ja9602051
  • 1995)
    • Totsuka R, Aizawa Y, Uesugi M, Okuno Y, Matsumoto T, Sugiura Y. “RNA cleavage by C-1027 chromophore, an enediyne antitumor antibiotic: High selectivity to an anticodon arm” Biochem. Biophys. Res. Commun. 1995;208:168-73. Available from: https://doi.org/10.1006/bbrc.1995.1319
  • 1994)
    • Okuno Y, Otsuka M, Sugiura Y. “Computer modeling analysis for enediyne chromophore-apoprotein complex of macromolecular antitumor antibiotic C-1027” J. Med. Chem. 1994;37:2266-73. Available from: https://doi.org/10.1021/jm00041a004