原著論文Original Article

  • 99)

    Accurate prediction of complex structure and affinity for a flexible protein receptor and its inhibitor

    Bekker, G., Kamiya, N., Araki, M., Fukuda, I., Okuno, Y., Nakamura, H.

                                                                                                                        Chem. Theory Comput.

                                                                                                                      13(6), 2389–2399, 2017

  • 98)

    Clinical sequencing using a next-generation sequencing-based multiplex gene assay in patients with advanced solid tumors

    Kou, T., Kanai, M., Yamamoto, Y., Kamada, M., Nakatsui, M., Sakuma, T., Mochizuki, H., Hiroshima, A., Sugiyama, A., Nakamura, E., Miyake, H., Minamiguchi, S., Takaori, K., Matsumoto, S., Haga, H., Seno, H., Kosugi, S., Okuno, Y., Muto, M.

                                                                                                                                    Cancer Science

                                                                                                                                                 2017.

  • 97)

    Brigatinib combined with anti-EGFR antibody overcomes osimertinib resistance in EGFR-mutated non-small-cell lung cancer

    Uchibori, K., Inase, N., Araki, M., Kamada, M., Sato, S., Okuno, Y., Fujita, N., Katayama, R.

                                                                                                                     Nature Communications.

                                                                                                                                             8, 2017.

  • 96)

    CGBVS‐DNN: prediction of compound‐protein Interactions based on deep learning

    Hamanaka, M., Tanaishi, Kei., Iwata, H., Ye, J., Pei, J., Hou, J., Okuno, Y.,

                                                                                                                        Molecular Informatics.

                                                                                                                                    36(1-2), 2016

  • 95)

    The effect of conformational flexibility on binding free energy estimation between kinases and their Inhibitors

    Araki, M., Kamiya, N., Sato, M., Nakatsui, M., Hirokawa, T., Okuno, Y.,

                             Journal of Chemical Information and Modeling.

                                         56(12), 2445-2456, 2016.

  • 94)

    Association between UGT1A1*28*28 genotype and lung cancer in the Japanese population

    Nishikawa, Y., Kanai, M., Narahara, M., Tamon, A., Brown, J.B., Taneishi, K., Nakatsui, M., Okamoto, K., Uneno, Y., Yamaguchi, D., Tomono, T., Mori, Y., Matsumoto, S., Okuno, Y., Muto, M.,

                                              Int J Clin Oncol.

                                                   2016.

  • 93)

    Novel 5-fluorouracil-resistant human esophageal squamous cell carcinoma cells with dihydropyrimidine dehydrogenase overexpression

    Kikuchi, O., Ohashi, S., Nakai, Y., Nakagawa, S., Matsuoka, K., Kobunai, T., Takechi, T., Amanuma, Y., Yoshioka, M., Ida, T., Yamamoto, Y., Yasushi, Okuno.,Miyamoto, S., Nakagawa, H., Matsubara, K., Chiba, T., Muto, M.,

    Am. J. Cancer Res.
    5(8), 2431-2440, 2015.

  • 92)

    Antipsychotics-Associated Serious Adverse Events in Children: An Analysis of the FAERS Database.

    Goji, Kimura., Kaori, Kadoyama., J.B. Brown., Tsutomu, Nakamura., Ikuya, Miki., Kohshi Nisiguchi., Toshiyuki, Sakaeda., Yasushi, Okuno.,

    Int. J. Med. Sci.
    12(2),135-140, 2015

  • 91)

    Reliable preeclampsia pathways based on multiple independent microarray data sets

    Kawasaki, K., Kondoh, E., Chigusa, Y., Ujita, M., Murakami, R., Mogami, H.,Brown, J.B., Okuno, Y.Konishi, I.

    Molecular Human Reproduction
    21(2), 217-224,2015

  • 90)

    Two Novel ALK Mutations Mediate Acquired Resistance to the Next-Generation ALK Inhibitor Alectinib

    Katayama, R., Friboulet, L., Koike, S., Lockerman, E.L., Khan, T.M., Gainorl, J.F., Iafrate, A.J., Takeuchi, K., Taiji, M., Okuno, Y.,Fujita, N., Engelman, J.A., Shaw, A.T.,

    Clinical Cancer Research
    20(22),5686-5696,2014