2017年Original Article

  • 2017)
    • Nakatsui M, Kamada M, Araki M, Okuno Y. “In silico drug discovery by supercomputer “K”” Nihon yakurigaku zasshi.Folia pharmacologica Japonica. 2017;149(6):281-287. Available from: https://doi.org/10.1254/fpj.149.281
    • Schneider G, Funatsu K, Okuno Y, Winkler D. “De novo Drug Design – Ye olde Scoring Problem Revisited” Molecular informatics. 2017;36(1-2). Available from: https://doi.org/10.1002/minf.201681031
    • Kondo T, Kanai M, Kou T, Sakuma T, Mochizuki H, Kamada M, Nakatsui M, Uza N, Kodama Y, Masui T, Takaori K, Matsumoto S, Miyake H, Okuno Y, Muto M. “Impact of BRCAness on the efficacy of oxaliplatin-based chemotherapy in patients with unresectable pancreatic cancer” JOURNAL OF CLINICAL ONCOLOGY. 2017;35(4). Available from: https://doi.org/10.1200/JCO.2017.35.4_suppl.250
    • Nakayama T, Imanaka Y, Okuno Y, Kato G, Kuroda T, Goto R, Tanaka S, Tamura H, Fukuhara S, Fukuma S, Muto M, Yanagita M, Yamamoto Y. “Analysis of the evidence-practice gap to facilitate proper medical care for the elderly: investigation, using databases, of utilization measures for National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB)” Environmental health and preventive medicine. 2017;22(1):51. Available from: https://doi.org/10.1186/s12199-017-0644-5
    • Morita K, Suzuki K, Maeda S, Matsuo A, Mitsuda Y, Tokushige C, Kashiwazaki G, Taniguchi J, Maeda R, Noura M, Hirata M, Kataoka T, Yano A, Yamada Y, Kiyose H, Tokumasu M, Matsuo H, Tanaka S, Okuno Y, Muto M, Naka K, Ito K, Kitamura T, Kaneda Y, Liu PP, Bando T, Adachi S, Sugiyama H, Kamikubo Y. “Genetic regulation of the RUNX transcription factor family has antitumor effects” The Journal of clinical investigation. 2017;127(7):2815-2828. Available from: https://doi.org/10.1172/JCI91788
    • Fujita K, Taneishi K, Inamoto T, Ishizuya Y, Takada S, Tsujihata M, Tanigawa G, Minato N, Nakazawa S, Takada T, Iwanishi T, Uemura M, Okuno Y, Azuma H, Norio N. “Adjuvant chemotherapy improves survival of patients with high-risk upper urinary tract urothelial carcinoma: a propensity score-matched analysis” BMC Urol. 2017;17(1):110. Available from: https://doi.org/10.1186/s12894-017-0305-4
    • Murakami R, Matsumura N, Brown, J.B, Higasa K, Tsutsumi T, Kamada M, Abou-Taleb H, Hosoe Y, Kitamura S, Yamaguchi K, Abiko K, Hamanishi J, Baba T, Koshiyama M, Okuno Y, Yamada R, Matsuda F, Konishi I, Mandai M. “Exome Sequencing Landscape Analysis in Ovarian Clear Cell Carcinoma Shed Light on Key Chromosomal Regions and Mutation Gene Networks” Am J Pathol. 2017;187:2246-2258. Available from: https://doi.org/10.1016/j.ajpath.2017.06.012
    • Terayama, K., Iwata, H., Araki, M., Okuno, Y., Tsuda, K. “Machine Learning Accelerates MD-based Binding-Pose Prediction between Ligands and Proteins” Bioinformatics. 2018;34(5):770-778. Available from: https://doi.org/10.1093/bioinformatics/btx638
    • Uneno Y, Taneishi K, Kanai M, Okamoto K, Yamamoto Y, Yoshioka A, Hiramoto S, Nozaki A, Nishikawa Y, Yamaguchi D, Tomono T, Nakatsui M, Baba M, Morita T, Matsumoto S, Kuroda T, Okuno Y, Muto M. “Development and validation of a set of six adaptable prognosis prediction (SAP) models based on time-series real-world big data analysis for patients with cancer receiving chemotherapy: A multicenter case crossover study” PloS One. 2017;12(8). Available from: https://doi.org/10.1371/journal.pone.0183291
    • Kiyan, W., Ito, A., Nakagawa, Y., Mukai, S., Mori, K., Arai, T., Uchino E, Okuno Y, Kuroki, H. “Relationships Between Quantitative Pulse-Echo Ultrasound Parameters from the Superficial Zone of the Human Articular Cartilage and Changes in Surface Roughness, Collagen Content or Collagen Orientation Caused by Early Degeneration” Ultrasound.Med.Biol. 2017;43(8):1703-1715. Available from: https://doi.org/10.1016/j.ultrasmedbio.2017.03.015
    • Bekker G, Kamiya N, Araki M, Fukuda I, Okuno Y, Nakamura H. “Accurate prediction of complex structure and affinity for a flexible protein receptor and its inhibitor” J. Chem. Theory Comput., 2017;13(6):2389-2399. Available from: https://doi.org/10.1021/acs.jctc.6b01127
    • Kou T, Kanai M, Yamamoto Y, Kamada M, Nakatsui M, Sakuma T, Mochizuki H, Hiroshima A, Sugiyama A, Nakamura E, Miyake H, Minamiguchi S, Takaori K, Matsumoto S, Haga H, Seno H, Kosugi S, Okuno Y, Muto M. “Clinical sequencing using a next-generation sequencing-based multiplex gene assay in patients with advanced solid tumors” Cancer Science, 2017;108(7):1440-1446. Available from: https://doi.org/10.1111/cas.13265
    • Uchibori K, Inase N, Araki M, Kamada M, Sato S, Okuno Y, Fujita N, Katayama R. “Brigatinib combined with anti-EGFR antibody overcomes osimertinib resistance in EGFR-mutated non-small-cell lung cancer” Nature Communications. 2017;8:14768. Available from: https://doi.org/10.1038/ncomms14768
    • Nakaoku T, Kohno T, Araki M, Niho S, Chauhan R, Knowles P.P,  Tsuchihara K, Matsumoto S, Shimada Y, Mimaki S, Ishii G, Ichikawa H, Nagatoishi S, Tsumoto K, Okuno Y, Yoh K, McDonald N.Q, Goto K. “A secondary RET mutation in the activation loop conferring resistance to vandetanib” Nature Communications, 2018;9(1):625. Available from: https://doi.org/10.1038/s41467-018-02994-7